Journal of Applied Physiology Fuel your research with LabChart
HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
QUICK SEARCH:   [advanced]


     

J Appl Physiol 10: 71-74, 1957;
8750-7587/57 $5.00
This Article
Right arrow Full Text (PDF)
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Fenichel, R. L.
Right arrow Articles by Seegers, W. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Fenichel, R. L.
Right arrow Articles by Seegers, W. H.

Studies on Human Clot Retraction

Richard L. Fenichel 1 and Walter H. Seegers 1

1 From the Department of Physiology and Pharmacology, Wayne State University College of Medicine, Detroit, Michigan

Dialysis of platelet homogenates removes material needed for clot retraction. Platelet homogenates, platelet dialysate and serotonin possess clot retraction potentialities. Plasma also contains material concerned with clot retraction and, when it is adsorbed with barium carbonate, it loses clot retraction activity. This activity, which is adsorbed on barium carbonate, can be eluted with dilute sodium citrate solutions. The adsorbed factor(s) is believed to be a protein. Thus, a plasma protein and dialyzable platelet substance(s), which includes serotonin, are concerned with clot retraction. Even in low concentration, glycerol interferes with clot retraction, and clots that do not retract are invariably transparent.

Submitted on August 6, 1956






HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS
Visit Other APS Journals Online