Journal of Applied Physiology Journal of Applied Physiology
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J Appl Physiol 10: 26-30, 1957;
8750-7587/57 $5.00
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Circulatory Depression Induced by High Levels of Positive Pressure Breathing Counteracted by Metaraminol (Aramine)

W. L. Morgan JR. 1, J. T. Binion 1, and S. J. Sarnoff 1

1 From the Laboratory of Cardiovascular Physiology, National Heart Institute, National Institutes of Health, Bethesda, Maryland

A sympathomimetic agent, Aramine (metaraminol), consistently ameliorated the hypotensive effects of positive pressure breathing in 17 anesthetized dogs for significant periods of time. Aramine was effective when administered either intramuscularly or intravenously. Whereas counterpressure provides support of the circulation by external mechanical means, it is proposed that Aramine provides a similar type of support by internally constricting the vascular bed. By this means, the protective effect of inadequately applied external counterpressure can be enhanced. The increased myocardial contractility induced by this agent is also thought to be of significance in the circulatory support provided.

Submitted on May 28, 1956




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Arch Surg, September 1, 1959; 79(3): 493 - 496.
[Abstract] [PDF]


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