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J Appl Physiol (April 11, 2003). doi:10.1152/japplphysiol.01058.2002
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Submitted on November 18, 2002
Accepted on April 8, 2003

Effect of Bupropion on hippocampal dopamine, serotonin and noradrenaline and on peripheral hormonal concentrations in the rat: an in vivo study

Maria Francesca Piacentini1, Ralph Clinckers2, Romain Meeusen3*, Sophie Sarre2, Guy Ebinger2, and Yvette Michotte2

1 Department of Human Physiology & Sportsmedicine, Vrije Universiteit Brussel, Brussels, Belgium; University Institute of Sport Sciences(IUSM), Rome, Italy
2 Department of Pharmaceutical Chemistry and Drug Analysis, Vrije Universiteit Brussel, Brussels, Belgium
3 Department of Human Physiology & Sportsmedicine, Vrije Universiteit Brussel, Brussels, Belgium

* To whom correspondence should be addressed. E-mail: rmeeusen{at}vub.ac.be.

The purpose of the present study was to administer an acute dose of the dual dopamine noradrenaline reuptake blocker bupropion in freely moving rats and to monitor the extracellular neurotransmitter concentrations in the hippocampus via in vivo microdialysis and the peripheral hormonal concentrations via catheterization. A microdialysis probe was inserted in the hippocampus and samples for serotonin, dopamine and noradrenaline were collected every 20 minutes before and after the injection of 17 mg kg-1 of bupropion for a total sampling time of 180 minutes. A catheter was placed in the vena femoralis of the second group of rats and blood samples were collected before and after bupropion injection for quantification of growth hormone, prolactin (PRL), corticosterone, adrenocorticotropin hormone and beta-endorphins. All neurotransmitter levels (dopamine, noradrenaline and serotonin) significantly increased after bupropion injection. This was accompanied by a significant decrease in PRL concentrations while the other hormones showed no statistically significant variation. It can therefore be concluded that, although bupropion has dual reuptake proprieties, the observed effects both at the central and at the peripheral level seem to be ruled by the dopaminergic system.




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