Decompression sickness (DCS) after air diving has been treated with success by means of combined normobaric oxygen breathing and intravascular perfluorocarbon (PFC) emulsions causing increased survival rate and faster bubble clearance from the intravascular compartment. The beneficial PFC effect has been explained by the increased transport capacity of oxygen and inert gases in blood. However, previous reports have shown that extra vascular bubbles in lipid tissue of rats suffering from DCS, will initially grow during oxygen breathing at normobaric conditions. We hypothesize that the combined effect of normobaric oxygen breathing and intravascular PFC infusion could lead to either enhanced extra vascular bubble growth upon decompression due to the increased oxygen supply, or that PFC infusion could lead to faster bubble elimination, due to the increased solubility and transport capacity in blood for nitrogen causing faster nitrogen tissue desaturation. In anaesthetized rats decompressed from a 60 minutes hyperbaric exposure breathing air at 385 kPa, we visually followed the resolution of micro air bubbles injected into abdominal adipose tissue while the rats breathed either air, oxygen or oxygen breathing combined with PFC infusion. All bubble observations were done at 101.3 kPa pressure. During oxygen breathing with or without combined PFC infusion, bubbles disappeared faster when compared to air breathing. Combined oxygen breathing and PFC infusion caused faster bubble disappearance when compared to oxygen breathing. The combined effect of oxygen breathing and PFC infusion did neither prevent nor increase transient bubble growth time, rate- or growth ratio when compared to oxygen breathing alone. We conclude, that oxygen breathing in combination with PFC infusion cause faster bubble disappearance and does not exacerbate transient bubble growth. PFC infusion may be a valuable adjunct therapy during the first aid treatment of DCS at normobaric conditions.