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J Appl Physiol (July 2, 2009). doi:10.1152/japplphysiol.00467.2009
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Submitted on May 4, 2009
Revised on June 24, 2009
Accepted on June 29, 2009

MOLECULAR CONTROL OF CIRCADIAN METABOLIC RHYTHMS

Siming Li1 and Jiandie D. Lin1*

1 University of Michigan Medical Center

* To whom correspondence should be addressed. E-mail: jdlin{at}umich.edu.

Circadian metabolic rhythms are fundamental to the control of nutrient and energy homeostasis as well as the pathogenesis of metabolic disease, such as obesity, lipid disorders, and type 2 diabetes. This temporal organization of tissue metabolism is coordinated through reciprocal crosstalk between the biological timing system and the metabolic regulatory networks. In this review, we discuss the signaling mechanisms that serve to couple metabolic regulation to the circadian pacemaker, in particular the role of the PGC-1 transcriptional coactivators in integrating clock and energy metabolism.






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